After two weeks at the box office top spot, the vampires of Twilight got bitten by Sandra Bullock and a sports-family-drama movie.

The good news is that as expected, overall business during the weekend slid a bit after Thanksgiving but still pretty high—21 percent—as compared to last year. The bad news is that attendance isn’t doing as well. A lot of the movies lost about 60 percent of their audiences over weekend.

Moving to the top spot on its third week, The Blind Side hit $20 million over the weekend for a total of $129 million within 17 days. Given this movie’s high opening of $34.1 million (and her last movie, The Proposal, doing pretty well), it would seem like the year 2009 is becoming Bullock’s movie year.

Falling down by 63 percent is The Twilight Saga: New Moon, the second part of the vampire romance franchise, as it earned $15 million for a total $255 million. However, it beat the first Twilight movie in final tally as it grossed $255 million in 17 days.  In fact, it’s even done better than the last Thanksgiving Harry Potter movie, Harry Potter and the Goblet of Fire.

At third place was the newly-released movie Brothers, which scored only a modest $10 million in 2,088 sites despite its high-profile cast of Tobey Maguire, Jake Gyllenhaal and Natalie Portman. Another new movie, the Matt Dillon-starrer Armored, opened at sixth place with $6.6 million at 1,915 sites. The third new movie for the weekend was Robert DeNiro’s drama Everybody’s Fine, which opened at tenth place with about $4 million at 2,133 sites.

Still around at fourth place is Disney’s A Christmas Carol, down by 52 percent as it grossed $7.5 million for a total of $115 million. Another holdover at fifth place, Old Dogs, dropped 59 percent for $6.9 million for a total of $33 million.

Roland Emmerich’s disaster flick 2012 was at seventh place, down by 63 percent with $6.6 million for a total of $148 million in 24 days. This was followed by the Rain-starrer action movie Ninja Assassin, up by only $5 million for a total of $29 million in 12 days at eighth place. Likewise, the animated sci-fi flick Planet 51 is trying to hold on at the ninth slot with $4.3 million for a total of $35 million.

Three movies—The Fantastic Mr. Fox, Precious, and The Road—all dropped out of the top ten.  However, George Clooney’s possible Oscar contender Up in the Air made quiet waves at the thirteenth slot as it grossed over $1 million despite being released in only 15 theaters.

Coming up next weekend are Disney’s 2D animation The Princess and the Frog as well as Clint Eastwood’s Invictus with Morgan Freeman and Matt Damon. (Joseph N)

Sources: Joblo, Box Office Mojo